DownloadTechnical Publication - Targeting Neutrophil Adhesive Events to Address Vaso-Occlusive Crisis in Sickle Cell Patients
V.A. Morikis, A.A. Hernandez, J.L. Magnani, M. Sperandio, S.I. Simon
Frontiers in Immunology, 1 April 2021, Volume 12, Article 663886
DownloadTechnical Publication - The Clinical Impact of Glycobiology: Targeting Selectins, Siglecs and Mammalian Glycans
B. A.H. Smith and C.R. Bertozzi
Nat Rev Drug Discov, 2021.
DownloadTechnical Publication - Glycomimetic Drugs — A New Source of Therapeutic Opportunities
J. L. Magnani and B. Ernst
Discovery Medicine, 2009, Issue 8, Number 43, 247-252
DownloadTechnical Publication - From Carbohydrate Leads to Glycomimetic Drugs
B. Ernst and J. L. Magnani
Nature Reviews Drug Discovery, 2009, Vol 8, Number 8, 661-677
DownloadTechnical Publication - The Discovery, Biology, and Drug Development of Sialyl Lea and Sialyl Lex
J. L. Magnani
Archives of Biochemistry and Biophysics, 2004, Vol 426, Issue 2, 122–131
DownloadTechnical Publication - Targeting hematologic malignancies by inhibiting E-selectin: A sweet spot for AML therapy?
Geoffrey L. Uy a , Daniel J. DeAngelo, Jay N. Lozier , Dennis M. Fisher, Brian A. Jonas, John L. Magnani, Pamela S. Becker, Hillard M. Lazarus, Ingrid G. Winkler
DownloadTechnical Publication - Combining 5-azacitidine with the E-selectin antagonist uproleselan is an effective strategy to augment responses in myelodysplasia and acute myeloid leukaemia
Anoop K. Enjeti, William E. Fogler, Theodore A. G. Smith, Lisa F. Lincz, Danielle R. Bond, John L. Magnani
DownloadASH 2022 (Poster) - Uproleselan Added to Cladribine Plus Low Dose Cytarabine (LDAC) in Patients with Treated Secondary Acute Myeloid Leukemia (TS AML)
E.A. Huante, H. Kantarjian, K.S. Chien, C.D. DiNardo, N. Short, A. Maiti, G. Montalban, N. Daver, J.D. Kawedia , K. Bowie, S. A. Pierce, F. Ravandi, M. Konopleva, G. Garcia Manero , and T. M. Kadia
DownloadTechnical Publication - Phase 1/2 Study of Uproleselan Added to Chemotherapy in Patients with Relapsed or Refractory Acute Myeloid Leukemia
D. DeAngelo, B. Jonas, J. Liesveld, D. Bixby, A. Advani, P. Marlton, J. Magnani, H. Thackray, E. Feldman, M. O'Dwyer, P. Becker
DownloadASH 2020 (Presentation) - Targeting E-selection with GMI-1271 Overcomes Microenvironment-mediated Resistance to Venetoclax/HMA Therapy
K.H. Chang, M. Muftuoglu, W. Zhang, M. Basyal, L. Ostermann, W.E. Fogler, J.L. Magnani, M. Andreeff
DownloadSOHO 2020 (Poster) - Targeting E-Selectin with GMI-1271 Overcomes Microenvironment-Mediated Resistance to Venetoclax / HMA Therapy
K.H. Chang, W. Zhang , M. Basyal, L. Ostermann , W.E. Fogler , J.L. Magnani and M. Andreeff
DownloadAACR 2020 (Poster) - Enhanced Survival of Lethally-Irradiated Mice with HSC Reconstitution in Combination with the E-Selectin Antagonist, GMI-1271 (Uproleselan)
W.E. Fogler, D. Daniel, S. Barnes, A. Wong, D. Draper, J.L. Magnani
DownloadAACR 2020 (Poster) - Transcriptome Profiling of ST3GAL4 and FUT7 in Multiple Tumor Types and Prognostic Value in Adult Acute Myeloid Leukemia
W.E. Fogler, V. Deng, D. Stewart, M. Jarman, S. Daminelli, A. Carr, J.L. Magnani
DownloadTechnical Publication - Endothelial E-selectin inhibition improves acute myeloid leukaemia therapy by disrupting vascular niche-mediated chemoresistance
V. Barbier, J. Erbani, C. Fiveash, J.M. Davies, J. Tay,
M.R. Tallack, J. Lowe, J.L. Magnani, D.R. Pattabiraman, A.C. Perkins, J. Lisle, J.E.J. Rasko, J-P Levesque, I.G. Winkler
Nature Communications, (2020)11:2042, https://doi.org/10.1038/s41467-020-15817-5
DownloadASH 2019 (Poster) - Alliance A041701 - A Randomized Phase 2/3 Study of Conventional Chemotherapy +/- Uproleselan (GMI-1271) in Older Adults with Acute Myeloid Leukemia Receiving Intensive Induction Chemotherapy
G.L. Uy, J. Yin, H.D. Klepin, S. Dinner, A. Jaslowski, S. A. Strickland, J.L. Liesveld, J.C. Byrd, R.M. Stone
DownloadASH 2019 (Poster) - Synergistic Targeting of BTK and E-Selectin/CXCR4 in the Microenvironment of Mantle Cell Lymphomas
M. Basyal, W. Zhang, N.B. Patel, S. Piya, H. Zhang, W.E. Fogler, W.G. Rice, J.L. Magnani, G. Borthakur, M. Andreeff
DownloadASH 2019 (Poster) - Transcriptome Profiling of Glycosylation Genes Identifies Correlation with E-selectin Ligand Expression and Clinical Outcome in AML
A.R. Leonti, L. Pardo, T.A. Alonzo, R.B. Gerbing, L.E. Brodersen, R.E. Ries, J.L. Smith, Q. Le, R. Aplenc, E.A. Kolb, J.L. Magnani, W.E. Fogler, M.R. Loken, S. Meshinchi
DownloadASH 2019 (Poster) - Blocking Vascular Niche E-Selectin Dampens AML Stem Cell Regeneration/Survival Potential In Vivo By Inhibiting MAPK/ERK and PI3K/AKT Signalling Pathways
I.G Winkler, V. Barbier, J. Tay, JP Levesque, J.L. Magnani, C.E. Fiveash, J..M Erbani
DownloadASH 2019 (Poster) - High E-selectin Ligand Expression Contributes to Chemotherapy-Resistance in Poor Risk Relapsed and Refractory (R/R) Acute Myeloid Leukemia (AML) Patients and can be Overcome with the Addition of Uproleselan
D.J. DeAngelo, B.A. Jonas, J.L. Liesveld, D.L. Bixby, A.S. Advani, P. Marlton, M.E. O’Dwyer, W.E. Fogler, J.L. Magnani, M. Chen, E.J. Feldman, H.M. Thackray, P.S. Becker
DownloadASH 2019 (Poster) - A Double-Blind, Placebo-Controlled, Phase 3 Registration Trial to Evaluate the Efficacy of Uproleselan (GMI-1271) with Standard Salvage Chemotherapy in Patients with Relapsed/Refractory (R/R) Acute Myeloid Leukemia
D.J. DeAngelo, H. Erba, B.A. Jonas, M.E. O'Dwyer, P. Marlton, G. Huls, J.L. Liesveld, B. Cooper, B. Bhatnagar, G.L. Uy, G. Cull, M. Armstrong, W. Fogler, M. Chen, J. Magnani, H. Thackray, E. Feldman, A.S. Advani, P.S. Becker
DownloadASCO 2019 (Poster) - Trials in Progress: A Phase 3 Trial to Evaluate the Efficacy of Uproleselan (GMI-1271) with Chemotherapy In Patients with Relapsed/Refractory Acute Myeloid Leukemia
D.J. DeAngelo, H. Erba, B.A. Jonas, M.E. O'Dwyer, P. Marlton, G. Huls, J.L. Liesveld, B. Cooper, B. Bhatnagar, M. Armstrong, W. Fogler, M. Chen, J. Magnani, H. Thackray, E. Feldman, A.S. Advani, and P.S. Becker
DownloadTechnical Publication - Inhibition of E-Selectin (GMI-1271) or E-selectin together with CXCR4 (GMI-1359) re-sensitizes multiple myeloma to therapy
B. Muz, F. Azab, M. Fiala, J. King, D. Kohnen, W. E. Fogler, T. Smith, J. L. Magnani, R. Vij, A. K. Azab
Blood Cancer Journal, 2019, https://doi.org/10.1038/
DownloadASH 2018 (Oral Presentation) – Uproleselan (GMI-1271), an E-Selectin Antagonist, Improves the Efficacy and Safety of Chemotherapy in Relapsed/Refractory (R/R) and Newly Diagnosed Older Patients with Acute Myeloid Leukemia: Final, Correlative and Subgroup Analyses
D.J. DeAngelo, B.A. Jonas, J.L. Liesveld, D.L. Bixby, A.S. Advani, P. Marlton, M.E. O’Dwyer, W.E. Fogler, C.D. Wolfgang, J.L. Magnani, H.M. Thackray, P.S. Becker
DownloadASH 2018 (Poster Presentation) – The Vascular Bone Marrow Niche Influences Outcome in Chronic Myeloid Leukemia
P.S. Sonika Godavarthy, S.C. Herkt, R. Kumar, N. Hayduk, E.S.Weissenberger, D. Aggoune, Y. Manavski, T. Lucas, K. Pan, J.M. Voutsinas, Q. Wu, M.C. Müller, T. Oellerich, V.G. Oehler, J. Lausen, D.S. Krause
DownloadASH 2018 (Poster Presentation) – E-Selectin Ligand Expression by Leukemic Blasts Is Associated with Prognosis in Patients with AML
S. Chien, J. Dai, J.L. Magnani, T.S. Sekizaki, W.E. Fogler, H.M. Thackray, K. Gardner, PA-C, E.H. Estey, P.S. Becker
DownloadASH 2018 (Poster Presentation) – Vascular E-Selectin Acts as a Gatekeeper Inducing Commitment and Loss of Self-Renewal in HSC Transmigrating through the Marrow Vasculature
I. G. Winkler, V. Barbier, J. Lowe, J. Tay, J.L. Magnani, P. Marlton, A.K. Mills, A. Perkins , C.E. Fiveash, J.M. Erbani, J. Levesque
DownloadAACR 2018 (Poster Presentation) - Glycomimetic Antagonist of E-selectin, GMI-1271, Enhances Therapeutic Activity of the Hypomethylating Agent, 5-Azacitidine, in the KG1 Model of AML
T.A.G. Smith, W.E. Fogler, J. Lee, J.L. Magnani
DownloadAACR 2018 (Poster Presentation) - Mobilization of Tumor-Primed, Marrow-Infiltrating Lymphocytes into Peripheral Blood with Inhibitors of E-Selectin or E-Selectin and CXCR4
W.E. Fogler, T.A.G. Smith, R.K. King, J.L. Magnani
DownloadASH 2017 (Oral Presentation) - GMI-1271 Improves Efficacy and Safety of Chemotherapy in R/R and Newly Diagnosed Older Patients with AML: Results of a Phase 1/2 Study
D.J. DeAngelo, B.A. Jonas, J.L. Liesveld, D.L. Bixby, A.S. Advani, P. Marlton, M.E. O’Dwyer, J.L. Magnani, H.M. Thackray, P.S. Becker
DownloadASH 2017 (Oral Presentation) - Vascular E-Selectin Mediates Chemo-Resistance in Acute Myeloid Leukemia Initiating Cells Via Canonical Receptors PSGL-1 (CD162) and Hcell (CD44) and AKT Signaling
I.G Winkler, J.M. Erbani, V. Barbier, J.M. Davies, J. Tay, C.E. Fiveash, J. Lowe, M. Tallack, J.L. Magnani, J-P. Levesque
DownloadEuropean Hematologic Association Congress 2017 (Poster) - GMI-1271, a Potent E-Selectin Antagonist, in Combination with Chemotherapy in Relapsed/Refractory AML: A Novel, Well-Tolerated Regimen with a High Remission Rate
D.J. DeAngelo, B.A. Jonas, J.L. Liesveld, M.E. O’Dwyer, D.L. Bixby, A.S. Advani, P. Marlton, J.L. Magnani, H.M. Thackray, P.S. Becker
DownloadEuropean Hematologic Association Congress 2017 (Poster) - GMI-1271, a Potent E-Selectin Antagonist, Combined with Induction Chemotherapy in Elderly Patients with Untreated AML: A Novel, Well-Tolerated Regimen with a High Remission Rate
D.J. DeAngelo, B.A. Jonas, D.L. Bixby, P.S. Becker, M.E. O’Dwyer, A.S. Advani, P. Marlton, J.L. Magnani, H.M. Thackray, J.L. Liesveld
DownloadASCO 2017 (Poster) - GMI-1271, a Novel E-Selectin Antagonist, in Combination with Chemotherapy in Relapsed/Refractory AML
D.J. DeAngelo, B.A. Jonas, J.L. Liesveld, M.E. O’Dwyer, D.L. Bixby, A.S. Advani, P. Marlton, J.L. Magnani, H.M. Thackray, P.S. Becker
DownloadASCO 2017 (Poster) - GMI-1271, a Novel E-Selectin Antagonist, Combined with Induction Chemotherapy in Elderly Patients with Untreated AML
D.J. DeAngelo, B.A. Jonas, D.L. Bixby, P.S. Becker, M.E. O’Dwyer, A.S. Advani, P. Marlton, J.L. Magnani, H.M. Thackray, J.L. Liesveld
DownloadTechnical Publication - E-selectin Ligands Recognised by HECA452 Induce Drug Resistance in Myeloma, Which Is Overcome by the E-selectin Antagonist, GMI-1271
A. Natoni, T.A.G. Smith, N. Keane, C. McEllistrim, C. Connolly, A. Jha, M. Andrulis, E. Ellert, M.S. Raab, S.V. Glavey, L. Kirkham-McCarthy, S.K. Kumar, S.C. Locatelli-Hoops, I. Oliva, W.E. Fogler, J.L. Magnani, M.E. O’Dwyer
Leukemia, 2017 Apr 25. doi: 10.1038/leu.2017.123. [Epub ahead of print] PMID: 28439107
DownloadAACR 2017 (Oral Presentation) - Inhibition of E-Selectin or E-selectin Together with CXCR4 Re-sensitizes Multiple Myeloma to Treatment
B. Muz, H. Bazai, A. Sekula, W. Fogler , T. Smith, J.L. Magnani, A.K. Azab
DownloadTechnical Publication - E-Selectin Inhibition Mitigates Splenic HSC Activation and Myelopoiesis in Hypercholesterolemic Mice With Myocardial Infarction
P. Dutta, F. F. Hoyer, Y. Sun, Y. Iwamoto, B. Tricot, R. Weissleder, J. L. Magnani, F. K. Swirski, M. Nahrendorf
Arterioscler Thromb Vasc Biol, 2016, Vol 36, Issue 9, 1802-1808
DownloadASH 2016 (Poster) - A Phase I/II Study of GMI-1271, a Novel E-selectin Antagonist, in Combination with Induction Chemotherapy in Relapsed/Refractory and Previously Untreated Elderly Patients with Acute Myeloid Leukemia; Results to Date
D.J. DeAngelo, J.L. Liesveld, B.A. Jonas, M.E. O'Dwyer, D,L. Bixby, J.L. Magnani, H.M. Thackray, P.S. Becker
DownloadASH 2016 (Poster) - Vascular E-selectin Protects Leukemia Cells from Chemotherapy by Directly Activating Pro-survival NF-kB Signalling Therapeutic E-selectin Blockade with GMI-1271 Inhibits NF-kB Activation in AML
I.G. Winkler, V. Barbier, M. Ward, M. Tallack, J. Lowe, J. Davies, J.Y. Tay, A. Perkins, J. L. Magnani, J. Levesque
DownloadASH 2016 (Poster) - E-selectin Antagonist GMI-1271 Shows a Favorable Safety, PK and Bleeding Profile in Phase I Studies of Healthy Volunteers
D. E. Angelini, S. Devata, A.E. Hawley, S.A. Blackburn, S. Grewal, M.V. Hemmer, H. Flanner, W. Kramer, W.E. Parker, Y. Li, D.D. Myers, J.B. Froehlich, J.L. Magnani, H.M. Thackray, T.W. Wakefield, S.L. Sood
DownloadEuropean Hematologic Association Congress 2016 (Poster) - Results of a Phase I Study of GMI-1271, a Potent E-Selectin Antagonist in Combination with Induction Chemotherapy in Relapsed/Refractory AML: A Novel, Well-Tolerated Regimen with a High Remission Rate
D.J. DeAngelo, M.E. O’Dwyer, P.S. Becker, J.L. Liesveld, D.L. Bixby, J.L. Magnani, H.M. Thackray, B.A. Jonas
DownloadTechnical Publication - Dormant Breast Cancer Micrometastases Reside in Specific Bone Marrow Niches That Regulate Their Transit to and From Bone
T.T. Price, M. L. Burness, A. Sivan, M. J. Warner, R. Cheng, C. H. Lee, L. Olivere, K. Comatas, J. Magnani, H. K. Lyerly, Q. Cheng, C. M. McCall, D. A. Sipkins
Science Translational Medicine, 2016, Vol 8, Issue 340, 340ra73
DownloadASH 2015 (Oral Presentation) - Mobilization of CD8+ Central Memory T-Cells with Enhanced Reconstitution Potential in Mice By a Combination of G-CSF and GMI- 1271-Mediated E-Selectin Blockade
I.G. Winkler, V. Barbier, K.J. Radford, J.M. Davies, J. Levesque, T.A.G. Smith, W.E. Fogler, J.L. Magnani
DownloadASH 2015 (Poster) - First in Human Phase 1 Single Dose Escalation Studies of the E-Selectin Antagonist GMI-1271 Show a Favorable Safety, Pharmacokinetic, and Biomarker Profile
S. Devata, S.L. Sood, M.V. Hemmer, H. Flanner, W. Kramer, C. Nietubicz, A. Hawley, Y. Li, D.E. Angelini, D.D. Myers, S. Blackburn, J. Froehlich, T.W. Wakefield, J.L. Magnani, H.M. Thackray
DownloadASH 2015 (Poster) - E-Selectin Ligand Expression increases with Progression of Myeloma and Induces Drug Resistance in a Murine Transplant Model, Which is Overcome By the GlycoMimetic E-Selectin Antagonist, GMI-1271
A. Natoni, T. A.G. Smith, N. Keane, S. Locatelli-Hoops, I. Olivera, W.E. Fogler, J.L. Magnani, M. O’Dwyer
DownloadAACR 2015 (Poster) - Metastatic Breast Cancer Cell Communication Within a Pro-Dormancy Bone Marrow Niche
T. T. Price, C. H. Lee, Q. Cheng, K. Lyerly, W. E. Folger, J. L. Magnani, D. A. Sipkins
DownloadASH 2014 (Oral Presentation) - Vascular Niche E-Selectin Protects Acute Myeloid Leukemia Stem Cells from Chemotherapy
I. G. Winkler, V. Barbier, D. R. Pattabiraman, T. J. Gonda, J. L. Magnani, J. Levesque
DownloadASH 2014 (Oral Presentation) - Mobilisation of Reconstituting HSC Is Boosted By Synergy Between G-CSF and E-Selectin Antagonist GMI 1271
I. G. Winkler, V. Barbier, A. C. Perkins, J. L. Magnani, J. Levesque
DownloadASH 2014 (Oral Presentation) - The Vascular Niche is Involved in Regulating Leukemic Stem Cells in Murine Chronic Myelogenous Leukemia
D. Aggoune, J. L. Magnani, R. A. Van Etten, D. S. Krause
DownloadASH 2014 (Oral Presentation) - E-Selectin Inhibitor GMI-1271 Works in Combination with Low-Molecular Weight Heparin to Decrease Venous Thrombosis and Bleeding Risk in a Mouse Model
D. D. Myers Jr., S. K. Wrobleski, K. Kelsey, D. Farris, D. A. Jose, H. K. Peter, S. L. Sood, T. W. Wakefield, J. L. Magnani
DownloadASH 2014 (Poster) -Multiple Myeloma Cells Express Functional E-Selectin Ligands Which Can be Inhibited Both in vitro and in vivo Leading to Prolongation of Survival in a Murine Transplant Model
A. Natoni, M. Moschetta, S. Glavey, P. Wu, G. J. Morgan, L. Joshi, J. L. Magnani, I. M. Ghobrial, M. E O'Dwyer
DownloadAACR 2014 (Poster) - A Small Molecule Glycomimetic Antagonist of E-selectin (GMI-1271) Prevents Pancreatic Tumor Metastasis and Offers Improved Efficacy of Chemotherapy
M. M. Steele, P. Radhakrishnan, J. L. Magnani, M. A. Hollingsworth
DownloadAACR 2014 (Poster) - Exploration of a Potent E-selectin Antagonist (GMI-1271) as a Potential Therapeutic for Treating Breast Cancer Metastasis to the Lung and Bone
M. Esposito, N. Campbell, Y. Wei, Q. Qiu, J. L. Magnani, Y. Kang
DownloadAACR 2014 (Poster) - Breast Cancer Cells Metastasize to Bone through E-Selectin Positive Vascular Gateways
T. Price, M. Burness, A. Sivan, R. Cheng, J. L. Mangnani, D. A. Sipkins
DownloadASH 2013 (Poster) - Administration of E-selectin Antagonist GMI-1271 Improves Survival to High-Dose Chemotherapy by Alleviating Mucositis and Accelerating Neutrophil Recovery
I. G. Winkler, V. Barbier, S. Z. Hasnain, J. P. Levesque, J. L. Magnani, M. A. McGuckin
DownloadASH 2013 (Oral Presentation) - Adhesion of Acute Myeloid Leukemia Blasts to E-Selectin in the Vascular Niche Enhances Their Survival By Mechanisms Such as Wnt Activation
S. Chien, S. U. Haq, M. Pawlus, R. T. Moon, E. H. Estey, F. R. Appelbaum, M. Othus, J. L. Magnani, P. S. Becker
DownloadTechnical Publication - Vascular Niche E-selectin Regulates Hematopoietic Stem Cell Dormancy, Self Renewal and Chemoresistance
I. G. Winkler, V. Barbier, B. Nowlan, R.N. Jacobsen, C. E. Forristal, J. T. Patton, J. L. Magnani & J. Lévesque
Nature Medicine, 2012, Vol 18, Issue 11, 1651-1657
DownloadASH 2012 (Poster) - A Novel Small Molecule E-Selectin Inhibitor GMI-1271 Blocks Adhesion of AML Blasts to E-Selectin and Mobilizes Blood Cells in Nodscid IL2Rgc-/- Mice Engrafted with Human AML
S. Chien, X. Zhao, M. Brown, A. Saxena, J. T. Patton, J. L. Magnani, P. S. Becker
DownloadASH 2012 (Poster) - Novel E-Selectin Antagonist GMI-1271 Decreases Venous Thrombosis without Increased Bleeding Potential in a Mouse Model
D. D. Myers Jr., D. L. Culmer, J. A. Diaz, A. E. Hawley, P. K. Henke, S. L. Sood, R. E. Sigler, A. T. Obi, J. T. Patton, T. W. Wakefield, J. L. Magnani
DownloadASH 2021 (Poster) - Co-targeting E-selectin/CXCR4 with GMI-1359 Facilitates AML Stem Cell Mobilization and Protects BM Niches from Anti-leukemia Therapy
K.H. Chang, T. Zal, M. Basyal, L. Ostermann, M. Muftuoglu1, P.Y. Mak, Y. Jia, W. Tao, M.A. Zal, W.E. Fogler, J.L. Magnani, W. Zhang, B.Z. Carter, and M. Andreeff
DownloadASH 2021 (Poster) - FLT3 Inhibitors Upregulate CXCR4 and E-selectin Ligands and CD44 via ERK Suppression in AML Cells, and Blockade of CXCR4 and E-selectin Signaling with GMI-1359 Overcomes AML Resistance to Quizartinib In Vitro and In Vivo
Y. Jia, M. Basyal, L. Ostermann, K.H. Chang, Q. Zhang, W.E. Fogler, J.L. Magnani, Marina Konopleva, W. Zhang, and M. Andreeff
DownloadAACR 2021 (Poster) - Development of GMI-1359, a Novel Agent Targeting Tumor-Microenvironment Cross-talk in Bone Metastatic Breast Cancer
P. Kelly Marcom, T.T. Price, A.S. Murray, W.E. Fogler, J.L. Magnani, H. Thackray, E. Feldman, D.A. Sipkins
DownloadASH 2020 (Poster) - Dual CXCR4 and E-Selectin Inhibition (GMI-1359) Rapidly Increases AML Cellular Motility Prior to Intravasation and Vascular Niche Depletion Observed by Intravital Bone Marrow 2-Photon Microscopy
T. Zal, M.A. Zal, M. Rytelewski, K.H. Chang, R. Jacamo, W.E. Fogler, J.L. Magnani, M. Andreeff
DownloadASH 2020 (Poster) - Combined Blockade of E-selectin and CXCR4 (GMI-1359) Enhances Anti-Leukemia Effect of FLT3 Inhibition (Sorafenib) and Protects Hematopoiesis in Pre-Clinical AML Models
W. Zhang, K.H. Chang, M. Basyal, Y. Jia, L. Ostermann, W.E. Fogler, J.L. Magnani, M.A. Zal, T. Zal, M. Andreeff
DownloadAACR 2020 (Poster) - Combined Targeting of E-selectin/CXCR4 and FLT3 by GMI-1359 and Sorafenib Effectively Reduces Leukemia Cell Burden and Protects Normal Hematopoiesis in a Patient-derived AML Xenograft Model
W. Zhang, K.H. Chang, M. Basyal, Y. Jia, L. Ostermann, W.E. Fogler, J.L. Magnani, M. Andreeff
DownloadTechnical Publication - Bone vascular niche E-selectin induces mesenchymal–epithelial transition and Wnt activation in cancer cells to promote bone metastasis
M. Esposito, N. Mondal, T. M. Greco, Y. Wei, C. Spadazzi. S-C Lin, H. Zheng, C. Cheung, J. L. Magnani, S-H Lin, I. M. Cristea, R. Sackstein, Y. Kang
Nature Cell Biology, https://doi.org/10.
DownloadTechnical Publication - Dormant breast cancer micrometastases reside in specific bone marrow niches that regulate their transit to and from bones
T. T. Price, M. L. Burness, A. Sivan, M. J. Warner, R. Cheng, C. H. Lee, L. Olivere, K. Comatas, J. L. Magnani, H. K. Lyerly, Q. Cheng, C. M. McCall, D. A. Sipkins
Science Translational Medicine, 25 May 2016, Vol 8, Issue 340
DownloadTechnical Publication - Inhibition of E-Selectin (GMI-1271) or E-selectin together with CXCR4 (GMI-1359) re-sensitizes multiple myeloma to therapy
B. Muz, F. Azab, M. Fiala, J. King, D. Kohnen, W. E. Fogler, T. Smith, J. L. Magnani, R. Vij, A. K. Azab
Blood Cancer Journal, 2019, https://doi.org/10.1038/
DownloadAACR 2018 (Poster Presentation) - Single Ascending Dose Pharmacokinetics of the the E-Selectin/CXCR4 Dual Antagonist GMI-1359 after Intravenous Infusions of 0.1, 0.2, 0.5, 1, 2, AND 3.5 MG/KG to Healthy Volunteers
H. Flanner, W. Kramer, A. Sarkar, C.D. Wolfgang, J. Peterson, H. Thackray, J.L. Magnani
DownloadAACR 2018 (Poster Presentation) - Mobilization of Tumor-Primed, Marrow-Infiltrating Lymphocytes into Peripheral Blood with Inhibitors of E-Selectin or E-Selectin and CXCR4
W.E. Fogler, T.A.G. Smith, R.K. King, J.L. Magnani
DownloadAACR 2018 (Poster Presentation) - Dual E-Selectin and CXCR4 Inhibition Reduces Tumor Growth and Metastatic Progression in an Orthotopic Model of Osteosarcoma
W. Ju, C.L. Yeung, A. Mendoza, M. Murgai, S. Kaczanowska, J. Zhu, D.A. Stewart, W.E. Fogler, J.L. Magnani, R.N. Kaplan
DownloadAACR 2017 (Oral Presentation) - Inhibition of E-Selectin or E-selectin Together with CXCR4 Re-sensitizes Multiple Myeloma to Treatment
B. Muz, H. Bazai, A. Sekula, W. Fogler , T. Smith, J.L. Magnani, A.K. Azab
DownloadASH 2016 (Poster) - The Dual E-selectin/CXCR4 Antagonist GMI-1359 Exerts Anti-leukemia Efficacy Against FLT3-ITD-mutated Acute Myeloid Leukemia in A Patient-derived Xenograft Murine Model
W. Zhang, C. Ly, Q. Zhang, H. Mu, V.L. Battula, N.B. Patel, W. Schober, X. Han, W.E. Fogler, J.L. Magnani, M. Andreeff
DownloadASH 2016 (Poster) - Administration of the Dual E-Selectin/CXCR4 Antagoist, GMI-1359, Results in a Unique Profile of Tumor Mobilization from the Bone Marrow and Facilitation of Chemotherapy in a Murine Model of FLT3 ITD AML
W.E. Fogler, H. Flanner, C. Wolfgang, J. Smith, H. Thackray, J.L. Magnani
DownloadSITC 2016 (Poster) - Combination of a Glycomimetic Antagonist to E-Selectin and CXCR4, GMI-1359, with an Anti-PD-L1 Antibody Attenuates Regulatory T-Cell Infiltration and Accelerates Time to Complete Response in the Murine CT26 Tumor Model
W.E. Fogler, M. Franklin, M. Thayer, D. Saims, and J.L. Magnani
DownloadAACR 2016 (Poster) - The E-selectin/CXCR4 Inhibitor GMI-1359 Effectively Mobilizes Bone Marrow Leukemia Cells and Enhances FLT3 Inhibitor Efficacy in a Murine AML Model
W. Zhang, H. Mu, Q. Zhang, N.B. Patel, W.E. Fogler, J.L. Magnani, M. Andreeff
DownloadAACR 2016 (Oral Presentation) - A Small Molecule Glycomimetic Antagonist of E-selectin and CXCR4 (GMI-1359) Delays Pancreatic Tumor Metastasis and Significantly Alters the Pancreatic Tumor Microenvironment
M.M. Steele, W.E. Fogler, J.L. Magnani, M.A. Hollingsworth
DownloadASH 2015 (Poster) - The Dual E-selectin/CXCR4 Inhibitor, GMI-1359, Enhances Efficacy of Chemotherapy in FLT3-ITD-Mutated Acute Myeloid Leukemia
W. Zhang, N.B Patel, W.E. Fogler, J.L. Magnani, M. Andreeff
DownloadAACR 2015 (Poster) - Dual E-Selectin and CXCR4 Inhibition Reduces Tumor Growth and Increases the Sensitivity to Docetaxel in Experimental Bone Metastases of Prostate Cancer
G. L. Gravina, A. Mancini, A. Colapietro, S D. Monache, A. Angelucci, A. Calgani, W. E. Fogler, J. L. Magnani, C. Festuccia
DownloadAACR 2015 (Poster) - A Small Molecule Glycomimetic Antagonist of E-selectin and CXCR4 (GMI-1359) Prevents Pancreatic Tumor Metastasis and Offers Improved Chemotherapy
M. M. Steele, W. E. Fogler, J. L. Magnani, M. A. Hollingsworth
DownloadTechnical Publication - Vascular Niche E-selectin Regulates Hematopoietic Stem Cell Dormancy, Self Renewal and Chemoresistance
I. G. Winkler, V. Barbier, B. Nowlan, R.N. Jacobsen, C. E. Forristal, J. T. Patton, J. L. Magnani & J. Lévesque
Nature Medicine, 2012, Vol 18, Issue 11, 1651-1657
DownloadASH 2011 (Oral Presentation) - Novel Dual E-Selectin-CXCR4 Inhibitors Mobilize Human Acute Myeloid Leukemia (AML) Cells in the NODscid IL2R?c-/- Xenograft and Confer Susceptibility to Cytarabine
S. Chien, X. Zhao, J. T. Patton, T. Smith, A. Sarkar, J. L. Magnani, F. R. Appelbaum, and P. S. Becker
DownloadTechnical Publication - Targeting Neutrophil Adhesive Events to Address Vaso-Occlusive Crisis in Sickle Cell Patients
V.A. Morikis, A.A. Hernandez, J.L. Magnani, M. Sperandio, S.I. Simon
DownloadASH 2018 (Poster Presentation) – A Novel and Potent Inhibitor of E-Selectin, GMI-1687, Attenuates Thrombus Formation and Augments Chemotherapeutic Intervention of AML in Preclinical Models Following Subcutaneous Administration
J. Peterson, M. Baek, S. Locatelli-Hoops, J. Lee, L. Deng, D.A. Stewart,T.A.G. Smith, D.D. Myers, W.E. Fogler, J.L. Magnani
DownloadASH 2018 (Poster Presentation) – A Novel Glycomimetic Compound (GMI-1757) with Dual Functional Antagonism to E-Selectin and Galectin-3 Demonstrates Inhibition of Thrombus Formation in an Inferior Vena Cava Model
J. Peterson, Y. Vohra, D.D. Myers, S. Locatelli-Hoops, J. Lee, L. Deng, T.A.G. Smith, W.E. Fogler, J.L. Magnani
Download4th Global NASH Congress (Poster) - Subcutaneous Administration of a Novel Glycomimetic Compound (GMI-1600) with Functional Antagonism to Galectin-3 Inhibits the Progression of NASH through the Attenuation of Fibrosis and Hepatocyte Ballooning
W.E. Fogler, J. Peterson, A. Sarkar, Y. Vohra, T.A.G. Smith, J. Lee, S. Locatelli-Hoops, J.L. Magnani
DownloadTechnical Publication - Clinical Trials and Applications of Galectin Antagonists
A. Girard, J. L. Magnani
DownloadASH 2020 (Presentation) - Early Initiation of Treatment with Rivipansel for Acute Vaso-Occlusive Crisis in Sickle Cell Disease (SCD) Achieves Earlier Discontinuation of IV Opioids and Shorter Hospital Stay: RESET Clinical Trial Analysis
C.D. Dampier, M.J. Telen, T. Wun, W.R. Smith, R.C. Brown, P. Desai, F.A. El Rassi, J. Kanter, B.R. Fuh, Y.D. Pastore, J.A. Rothman, J.G. Taylor, D. Readett, J.N. Lozier, J.L. Magnani, H.M Thackray,
K. L. Hassell
DownloadASCAT 2020 (Poster) - Early Initiation of Treatment with Rivipansel for Acute Vaso-Occlusive Crisis in Sickle Cell Disease (SCD) Achieves Earlier Discontinuation of IV Opioids and Shorter Hospital Stay: RESET Clinical Trial Analysis
J. Lozier, C. Dampier, M. Telen, T. Wun, W. Smith, C. Brown, P. Desai, F. El Rassi, J. Kanter, B. Fu, Y. Pastore, J. Rothman, J. Taylor, D. Readett, J.L. Magnani, H. Thackray, K. Hassell
DownloadFSCDR 2020 (Poster) - Efficacy and Safety of Rivipansel (GMI-1070) in the Treatment of Vaso-Occlusive Crisis in Hospitalized Patients With Sickle Cell Disease: Results From the RESET Phase 3 Study
C.D. Dampier, M.J. Telen, T. Wun, R.C. Brown, P. Desai, F.E. Rassi, B. Fuh, J. Kanter, Y. Pastore, J. Rothman, J.G. Taylor VI, D. Readett, K.M. Sivamurthy, B. Tammara, L. Tseng, K.L. Hassell
DownloadASH 2016 (Oral Presentation) - GMI-1070 (rivipansel) Inhibits E-selectin Recognition of Sialyl LewisX-Expressed on L-selectin and Blocks Integrin Activation and Arrest of Human Neutrophils
S.I. Simon, V.A. Morikis, S. Chase, J.L. Magnani
DownloadTechnical Publication - Randomized Phase 2 Study of GMI-1070 in SCD: Reduction in Time to Resolution of Vaso-occlusive Events and Decreased Opioid Use
M. J. Telen, T. Wun, T. L. McCavit, L. M. De Castro, L. Krishnamurti, S. Lanzkron, L. L. Hsu, W. R. Smith, S. Rhee, J. L. Magnani, and H. Thackray
Blood, 2015, Vol 125, Number 17, 2656-2664
DownloadASPHO 2014 (Oral Presentation) - Treating the Pain with GMI-1070
Timothy L. McCavit, M.D., M.S.
DownloadTechnical Publication - Phase 1 Study of the E-Selectin Inhibitor GMI 1070 in Patients with Sickle Cell Anemia
T. Wun, L. Styles, L. DeCastro, M. J. Telen, F. Kuypers, A. Cheung, W. Kramer, H. Flanner, S. Rhee, J. L. Magnani, H. Thackray
PLOS One, 2014, Vol 9, Issue 7, e101301
DownloadASH 2013 (Oral Presentation) - GMI-1070: Reduction in Time to Resolution of Vaso-Occlusive Crisis and Decreased Opioid Use in a Prospective, Randomized, Multi-Center Double Blind, Adaptive Phase 2 Study in Sickle Cell Disease
M.J. Telen, T. Wun, T. L. McCavit, L. M. DeCastro, L. Krishnamurti, S. Lanzkron, L. L. Hsu, W. R. Smith, S. Rhee, J. L. Magnani, H. Thackray
DownloadASH 2013 (Oral Presentation) - Effects of GMI-1070, a Pan-Selectin Inhibitor, On Pain Intensity and Opioid Utilization in Sickle Cell Disease
L. M. DeCastro, T. Wun, S. Lanzkron, W. R. Smith, K. L. Hassell, A. Kutlar, K. Smith-Whitley, S. Rhee, M. J. Telen, H. Thackray
DownloadASH 2013 (Poster) - An Analysis of the Pediatric Sub-Group From the Phase 2 Study of GMI-1070—A Novel Agent For The Vaso-Occlusive Crisis of Sickle Cell Anemia
T. L. McCavit, L. Krishnamurti, L. Hsu, C. T. Quinn, I. Odame, O. Alvarez, C. Driscoll, K. Smith Whitley, S. Rhee, T. Wun, M. Telen, H. Thackray
DownloadASH 2012 (Oral Presentation) - Pan-selectin Antagonist GMI-1070 affects Biomarkers of Adhesion, Activation and the Coagulation Cascade in Sickle Cell Adults at Steady State
J. L. Magnani, F. Kuypers, J. T. Patton, S. Larkin, L. Styles, L. DeCastro, M. Telen, T. Wun, H. Thackray
DownloadTechnical Publication - Vascular Niche E-selectin Regulates Hematopoietic Stem Cell Dormancy, Self Renewal and Chemoresistance
I. G. Winkler, V. Barbier, B. Nowlan, R.N. Jacobsen, C. E. Forristal, J. T. Patton, J. L. Magnani & J. Lévesque
Nature Medicine, 2012, Vol 18, Issue 11, 1651-1657
DownloadTechnical Publication - Reflection on the Discovery of Carcinoembryonic Antigen, Prostate-Specific Antigen, and Cancer Antigens CA125 and CA19-9
E. P. Diamandis, R. C. Bast, Jr., P. Gold, T. M. Chu, and J. L. Magnani
Clinical Chemistry, 2013, Vol 59, Issue 1, 22-31
DownloadASH 2011 (Oral Presentation) - Inhibition of E-Selectin Inflammatory Function by the Glycomimetic GMI-1070
S. I. Simon, S. Chase, H. Thackray, J. L. Magnani and T. Wun
DownloadASH 2011 (Oral Presentation) - Pan-Selectin Antagonist, GMI-1070 Decreases Venous Thrombosis in a Mouse Model
D. D. Myers Jr., P. K. Henke, J. A. Diaz, S. K. Wrobleski, A. E. Hawley, D. Slack, T. W. Wakefield, J. T. Patton, and J. L. Magnani
DownloadTechnical Publication - E-Selectin Ligands as Mechanosensitive Receptors on Neutrophils in Health and Disease
S. D. Chase, J. L. Magnani, and S. I. Simon
Annals of Biomedical Engineering, 2012, Vol 40, Issue 4, 849-859
DownloadTechnical Publication - P-selectin Glycoprotein Ligand Regulates the Interaction of Multiple Myeloma Cells With the Bone Marrow Microenvironment
A. K. Azab, P. Quang, F. Azab, C. Pitsillides, B. Thompson, T. Chonghaile, J. T. Patton, P. Maiso, V. Monrose, A. Sacco, H. T. Ngo, L. M. Flores, C. P. Lin, J. L. Magnani, A. L. Kung, A. Letai, R. Carrasco, A. M. Roccaro and I. M. Ghobrial
Blood, 2012, Vol 119, Number 6, 1468-1478
DownloadASH 2010 (Oral Presentation) - GMI-1070, a Pan-Selectin Inhibitor: Safety and PK In a Phase 1/2 Study In Adults with Sickle Cell Disease
L. Styles, T. Wun, L. M. De Castro, M. J. Telen, W. Kramer, H. Flanner, J. L. Magnani, and H. Thackray
DownloadASH 2010 (Poster) - GMI-1070, a Pan-Selectin Inhibitor: Safety and PK in a Phase 1/2 Study in Adults with Sickle Cell Disease
L. Styles, T. Wun, L. DeCastro, M. Telen, W. Kramer, H. Flanner, J. L. Magnani, H. Thackray
DownloadASH 2010 (Poster) - Effects of Selectin Antagonist GMI-1070 on the Activation State of Leukocytes in Sickle Cell Patients not in Crisis
S. I. Simon, S. Chase, S. K. Larkin, F. Kuypers, L. Styles, T. Wun, H. Thackray, and J. L. Magnani
DownloadTechnical Publication - Mightier than the Sickle Cell (editorial)
S. I. Simon and T. Wun
Blood, 2010, Vol 116, Number 10, 1622
DownloadTechnical Publication - GMI-1070, a Novel Pan-Selectin Antagonist, Reverses Acute Vascular Occlusions in Sickle Cell Mice
J. Chang, J. T. Patton, A. Sarkar, B. Ernst, J. L. Magnani, and P. S. Frenette
Blood, 2010, Vol 116, Number 10, 1779-1786
DownloadASH 2009 (Oral Presentation) - Absence or blockage of E-selectin-mediated Cell Adhesion delays Hematopoietic Stem Cell (HSC) turn-over and Enhances Chemoresistance.
I. G. Winkler, V. Barbier, B. Nowlan, T. Smith, J. T. Patton, J. L. Magnani, J. P. Levesque
DownloadAAPS 2009 (Poster) - Comparison of Predicted GMI-1070 Human Intravenous Pharmacokinetics from in silico PBPK and Allometric Scaling Models
H. Flanner, W. Kramer, J. Patton
DownloadASCO 2009 (Poster) - Role of Selectins in the Pathogenesis of Multiple Myeloma
A. K. Azab, F. Azab, J. M. Runnels, A. M. Roccaro, J. L. Magnani, A. Sarkar, K. C. Anderson, C. P. Lin, I. M. Ghobrial
DownloadASH 2008 (Oral Presentation) - Effects of Pan-Selectin Antagonist GMI-1070 on the Treatment of Vaso-Occlusion in Sickle Cell Mice
J. Chang, J. T. Patton, P. S. Frenette and J. L. Magnani
- Learn more about our Intellectual Property.
- Learn more about our Platform & Research.